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KMID : 0869220100140010044
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Journal of Korean Geriatric Psychiatry
2010 Volume.14 No. 1 p.44 ~ p.49
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Serum Levels of Homocysteine, Folate, and Vitamin B12 and Cognitive Function in Mild Cognitive Impairment and Alzheimer’s Disease
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Lee Jae-Hyuk
Lee Kang-Joon
Kim Hyun
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Abstract
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Objectives: This study aimed to investigate the serum levels of total homocysteine (tHcy), folate and vitamin B12 in Alzheimer’s
disease and mild cognitive impairment.
Methods: Sixty-one Alzheimer’s disease (AD) patients, forty mild cognitive impairment (MCI) patients and forty-four normal
controls were studied. The serum homocysteine (tHcy), folate, and vitamin B12 were measured and MMSE-K, GDS were evaluated
for cognitive function.
Results: Serum tHcy levels were significantly higher and folate levels were lower in patients with AD than in controls. And also
serum folate levels were lower in MCI than in controls. Vitamin B12 did not have a significant difference among three groups. The
serum homocysteine and folate levels shows significant correlation with MMSE-K.
Conclusion: Elevated tHcy levels and low blood levels of folate were associated with AD. Serum folate were significantly lower
levels in MCI than in controls. We suggested that serum tHcy, folate are useful risk markers for the development of cognitive dysfunction.
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KEYWORD
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Homocysteine·Folate·Vitamin B12·Alzheimer’s disease·Mild cognitive impairment.
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